| Jugador | Equipo | Goles | GJ | GC. | TL | TP |
| Denis Bouanga | LAFC | 24 | 19 | 1 | 0 | 4 |
| Cucho Hernández | Columbus | 20 | 12 | 2 | 0 | 6 |
| Georgios Giakoumakis | Atlanta | 19 | 12 | 7 | 0 | 0 |
| Luciano Acosta | FC Cincinnati | 18 | 9 | 1 | 1 | 7 |
| Brian White | Whitecaps FC | 16 | 8 | 8 | 0 | 0 |
| Hany Mukhtar | Nashville SC | 15 | 10 | 0 | 0 | 5 |
| Daniel Gazdag | Philadelphia | 15 | 3 | 0 | 0 | 12 |
| Julián Carranza | Philadelphia | 14 | 14 | 0 | 0 | 0 |
| Christian Benteke | DC United | 14 | 11 | 2 | 0 | 1 |
| Alan Pulido | Sporting KC | 14 | 9 | 2 | 0 | 3 |