| Jugador | Equipo | Goles | GJ | GC. | TL | TP |
| Sebastián Driussi | Austin FC | 25 | 17 | 3 | 0 | 5 |
| Daniel Gazdag | Philadelphia | 24 | 17 | 0 | 0 | 7 |
| Hany Mukhtar | Nashville SC | 23 | 14 | 2 | 1 | 6 |
| Brandon Vázquez | FC Cincinnati | 19 | 14 | 5 | 0 | 0 |
| Jesús Ferreira | FC Dallas | 18 | 14 | 2 | 2 | 0 |
| Cristian Arango | LAFC | 18 | 13 | 4 | 0 | 1 |
| Brenner | FC Cincinnati | 18 | 16 | 1 | 0 | 1 |
| Javier Hernández | LA Galaxy | 18 | 14 | 1 | 0 | 3 |
| Jeremy Ebobisse | SJ Earthquakes | 17 | 11 | 3 | 1 | 2 |
| Diego Rubio | Rapids | 16 | 7 | 3 | 2 | 4 |