| Jugador | Equipo | Goles | GJ | GC. | TL | TP |
| Christian Benteke | DC United | 23 | 11 | 9 | 0 | 3 |
| Luis Suárez | Miami | 20 | 18 | 2 | 0 | 0 |
| Lionel Messi | Miami | 20 | 17 | 1 | 1 | 1 |
| Denis Bouanga | LAFC | 20 | 13 | 0 | 0 | 7 |
| Juan Hernández | Columbus | 19 | 13 | 3 | 1 | 2 |
| Cristian Arango | Real SL | 17 | 8 | 7 | 0 | 2 |
| Daniel Gazdag | Philadelphia | 17 | 10 | 3 | 0 | 4 |
| Adrián Martínez | NYCFC | 16 | 16 | 0 | 0 | 0 |
| Jonathan Rodríguez | Portland T. | 16 | 11 | 4 | 0 | 1 |
| Gabriel Pec | LA Galaxy | 16 | 14 | 1 | 0 | 1 |