| Jugador | Equipo | Goles | GJ | GC. | TL | TP |
| Sam Surridge | Nashville | 20 | 13 | 2 | 0 | 5 |
| Lionel Messi | Miami | 19 | 17 | 0 | 2 | 0 |
| Evander | Cincinnati | 16 | 13 | 0 | 3 | 0 |
| Tai Baribo | Philadelphia | 16 | 12 | 3 | 0 | 1 |
| Dejan Joveljic | Sporting KC | 16 | 9 | 3 | 0 | 4 |
| Eric Maxim Choupo-Moting | NY Red Bulls | 16 | 10 | 1 | 0 | 5 |
| Hugo Cuypers | Chicago Fire | 15 | 10 | 2 | 0 | 3 |
| Martín Ojeda | Orlando | 14 | 12 | 0 | 0 | 2 |
| Brian White | Vancouver | 14 | 7 | 4 | 0 | 3 |
| Hany Mukhtar | Nashville | 14 | 10 | 1 | 0 | 3 |