| Jugador | Equipo | Goles | GJ | GC. | TL | TP |
| Lionel Messi | Miami | 18 | 16 | 0 | 2 | 0 |
| Sam Surridge | Nashville | 18 | 12 | 1 | 0 | 5 |
| Eric Maxim Choupo-Moting | NY Red Bulls | 16 | 10 | 1 | 0 | 5 |
| Evander | Cincinnati | 15 | 12 | 0 | 3 | 0 |
| Tai Baribo | Philadelphia | 15 | 11 | 3 | 0 | 1 |
| Martín Ojeda | Orlando | 14 | 12 | 0 | 0 | 2 |
| Hugo Cuypers | Chicago Fire | 14 | 9 | 2 | 0 | 3 |
| Denis Bouanga | LAFC | 14 | 7 | 0 | 0 | 7 |
| Petar Musa | FC Dallas | 13 | 12 | 0 | 0 | 1 |
| Dejan Joveljic | Sporting KC | 13 | 8 | 1 | 0 | 4 |