| Jugador | Equipo | Goles | GJ | GC. | TL | TP |
| Sam Surridge | Nashville | 16 | 10 | 1 | 0 | 5 |
| Tai Baribo | Philadelphia | 13 | 9 | 3 | 0 | 1 |
| Eric Maxim Choupo-Moting | NY Red Bulls | 12 | 7 | 1 | 0 | 4 |
| Evander | Cincinnati | 11 | 8 | 0 | 3 | 0 |
| Hugo Cuypers | Chicago Fire | 11 | 7 | 2 | 0 | 2 |
| Kévin Denkey | Cincinnati | 11 | 7 | 1 | 0 | 3 |
| Dejan Joveljic | Sporting KC | 11 | 7 | 1 | 0 | 3 |
| Lionel Messi | Miami | 10 | 9 | 0 | 1 | 0 |
| Brian White | Vancouver | 10 | 5 | 4 | 0 | 1 |
| Cristian Arango | SJ Earthquakes | 10 | 5 | 3 | 0 | 2 |