| Martes 21/08/21 | |||||
| Monarcas | 1 | 1 | Pachuca | Fin | |
| Pumas | 0 | 1 | Querétaro | Fin | |
| Puebla | 2 | 0 | Atlas | Fin | |
| Guadalajara | 1 | 0 | Necaxa | Fin | |
| Miércoles 22/08/22 | |||||
| Cruz Azul | Toluca | 21:00hs | |||
| León | América | 21:00hs | |||
| Tigres | Veracruz | 23:00hs | |||
| Lobos BUAP | Monterrey | 23:00hs | |||
| Tijuana | Santos | 23:06hs | |||